Pandemic H1N1 influenza A infection and (atypical) HUS—more than just another trigger?

  title={Pandemic H1N1 influenza A infection and (atypical) HUS—more than just another trigger?},
  author={Upton Allen and Christoph Licht},
  journal={Pediatric Nephrology},
Atypical hemolytic uremic syndrome (aHUS) is caused by mutations resulting in an exceedingly active alternative complement pathway. While today more than half a dozen genes are involved in aHUS pathology, only about 50% of carriers precipitate the disease. The reason for this phenomenon remains unclear, and triggering events like intercurrent infections have been postulated. In this context, reports on the development of (a)HUS in patients concomitantly diagnosed with pandemic H1N1 influenza A… CONTINUE READING
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