We have reported our experience with pancreatoduodenectomy with preservation of the pylorus performed in 37 patients for the treatment of chronic pancreatitis and its complications. The remaining pancreatic tail duct was occluded in 12 patients without anastomosis. Eight complications were observed and reoperation was necessary in two patients. Three complications and one reoperation occurred in the 25 patients who underwent pancreatogastrostomy. There was no operative mortality in the 37 patients. Six to 30 months postoperatively, 23 patients were free of complaints, the average weight gain was 7.6 kg, and so far no marginal ulcers have developed. Technically, pancreatogastrostomy is easy and complications may be identified early. According to our results, this type of anastomosis is the most favorable so far and is particularly suitable for the significant reduction of complications and deaths related to partial pancreatoduodenectomy.