Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports

  title={Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports},
  author={Elizabeth A. Koller and James T. Cross and P. Murali Doraiswamy and Saul N. Malozowski},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  • E. Koller, J. Cross, S. Malozowski
  • Published 1 September 2003
  • Psychology, Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Study Objective. To investigate the relative numbers and clinical characteristics of pancreatitis in patients treated with the atypical antipsychotic agents, clozapine, olanzapine, and risperidone, versus the conventional neuroleptic, haloperidol. 

Risk of Hospitalization for Acute Pancreatitis Associated with Conventional and Atypical Antipsychotics: A Population‐Based Case‐Control Study

The association of atypical and conventional antipsychotics with the risk of hospitalization for acute pancreatitis is studied to determine whether these drugs should be considered as a single treatment or a cocktail of drugs.

Quetiapine-Associated Pancreatitis in a Geriatric Critical Care Patient with Delirium

The case of a 78-year-old male who developed acute pancreatitis related to quetiapine that was administered for the treatment of delirium is reported, and clinicians should be alerted when treating critical care patients with antipsychotics.

Risperidone-induced acute pancreatitis

We report on an adolescent with Asperger's syndrome who developed acute pancreatitis during treatment with risperidone and citalopram. On discontinuation of psychopharmacotherapy, he fully recovered.

Pancreatitis as a rare side effect of paliperidone use

  • C. WuT. Lu
  • Medicine
    Taiwanese Journal of Psychiatry
  • 2020
A case of acute pancreatitis following the use of paliperidone is presented.

Application of an Empiric Bayesian Data Mining Algorithm to Reports of Pancreatitis Associated with Atypical Antipsychotics

  • M. Hauben
  • Medicine, Psychology
  • 2004
Study Objective. To compare the results from one frequently cited data mining algorithm with those from a study which was published in a peer‐reviewed journal, that examined the association of

Clozapine: Current perspective

The author conducted a review of studies that compared the efficacy, tolerability and indication for the use of clozapine in current perspectives for the treatment of resistant schizophrenia/ partial

Acute Necrotizing Pancreatitis following Long-Term Antipsychotic Use

This case illustrates that acute pancreatitis can occur long after the initiation of antipsychotic medications and may be mediated by mechanisms other than hypertriglyceridemia, and prescribers should be aware of the risk for drug-induced pancreatitis in patients stable on antipsychotics.

Olanzapine-induced pancreatitis: a case report.

Olanzapine is reported as the probable cause of acute pancreatitis in a patient without any known predisposing factors and should be monitored with glucose, lipid, pancreatic function and liver function tests, and the oanzapine should be discontinued if the results of these tests worsen.

Acute Pancreatitis Associated With Antipsychotic Medication: Evaluation of Clinical Features, Treatment, and Polypharmacy in a Series of Cases

Given the population frequency of psychosis and frequency of antipsychotic prescribing, published cases summarizing common clinical findings and antipsychotics associated with acute pancreatitis to updating earlier decision support are reviewed.

Acute Necrotizing Pancreatitis Following Olanzapine Treatment and 759C/T Polymorphism of HTR2C Gene: A Case Report.

A pharmacogenomic analysis revealed the presence of the 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C) -759C genotype which is related to increased risk for metabolic syndrome.



Olanzapine and pancreatitis.

Two patients with chronic schizophrenia were admitted with acute pancreatitis. Olanzapine was used by both patients and may represent a further example of drug-induced pancreatitis. Olanzapine is a

Drug-Induced Acute Pancreatitis

A definition of the mechanisms, pathogenesis and clinical features of acute pancreatitis is defined and the evidence for drugs, excluding ethanol, as being causative is critically reviewed.

Renal Impairment as a Possible Side Effect of Gabapentin

A bipolar I manic patient was treated successfully by adding gabapentin to perazine and clonazepam. Also initially tolerated well, an increase of creatinine after several weeks of GP (2000 mg) was

Asymptomatic pancreatitis associated with clozapine.

The monitoring of serum amylase levels during slow increase in clozapine is recommended; if leukocytosis or eosinophilia is present, the possibility of even a subclinical and asymptomatic pancreatitis should be considered.

Recurrent pancreatitis on clozapine re-challenge

A 39-year-old African-American man with chronic paranoid schizophrenia was administered clozapine for disabling psychotic symptoms after he had failed trials of traditional anti-psychotic drugs

Olanzapine-Induced Acute Pancreatitis

This is believed to be the first published report suspecting olanzapine, an atypical antipsychotic agent, to have caused acute hemorrhagic pancreatitis in a patient, leading to admission to the ICU and, eventually, death secondary to unrelenting peritonitis.

Clozapine-associated pancreatitis.

  • T. Cerulli
  • Medicine
    Harvard review of psychiatry
  • 1999
An adopted 34-year-old male with a history of schizoaffective disorder, non-insulin-dependent diabetes mellitus, obesity, and hypertension, who arrived at a local community hospital in a state of diabetic ketoacidosis, with nausea, vomiting, abdominal pain, and elevated amylase and lipase levels, diagnostic of acute pancreatitis.

Drug induced acute pancreatitis: incidence and severity.

To determine the incidence and severity of drug induced acute pancreatitis, data from 45 German centres of gastroenterology were evaluated and it was found that drugs rarely cause acute Pancreatitis, and drug induced pancreatitis usually runs a benign course.

Clozapine-associated diabetes.

Valproate‐Associated Pancreatitis

The clinical characteristics of valproate (VPA)‐associated pancreatitis appeared to be more frequent in young persons but may occur at any age, and awareness of the problem and early discontinuation of VPA may be effective in preventing serious reactions.