Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.

@article{Luchini2017PancreaticUC,
  title={Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.},
  author={Claudio Luchini and Antonio Pea and Gemma Lionheart and Andrea Mafficini and Alessia Nottegar and Nicola Veronese and Peter Chianchiano and Lodewijk A A Brosens and Micha{\"e}l No{\"e} and G. Johan A. Offerhaus and Raluca Yonescu and Yi Ning and Giuseppe Malleo and Giulio Riva and Paola Piccoli and Ivana Cataldo and Paola Capelli and Giuseppe Zamboni and Aldo Scarpa and Laura D Wood},
  journal={The Journal of pathology},
  year={2017},
  volume={243 2},
  pages={148-154}
}
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGC) is currently considered a morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC). In this study, we report clinical and pathological features of a series of 22 UCOGCs, including the whole exome sequencing of eight UCOGCs. We observed that 60% of the UCOGCs contained a well-defined epithelial component and that patients with pure UCOGC had a significantly better prognosis than… CONTINUE READING