Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus.

@article{Pieper1998PancreaticTR,
  title={Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus.},
  author={Galen M. Pieper and Mark B. Adams and Allan M. Roza},
  journal={Surgery},
  year={1998},
  volume={123 1},
  pages={89-95}
}
BACKGROUND There is insufficient evidence whether transplantation of the whole pancreas can reverse vascular complications associated with diabetes. In this study we investigated whether pancreatic transplantation in experimental diabetes reverses established defects in endothelium-dependent relaxation. METHODS Streptozotocin-induced diabetic rats underwent whole-pancreas transplantation after 12 weeks of disease. Endothelial function was evaluated 4 weeks after transplantation and compared… CONTINUE READING