Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

@article{Bernardo2008PancreaticTF,
  title={Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic $\beta$ cell},
  author={Andreia S Bernardo and Colin W. Hay and Kevin Docherty},
  journal={Molecular and Cellular Endocrinology},
  year={2008},
  volume={294},
  pages={1-9}
}
In recent years major progress has been made in understanding the role of transcription factors in the development of the endocrine pancreas in the mouse. Here we describe how a number of these transcription factors play a role in maintaining the differentiated phenotype of the beta cell, and in the mechanisms that allow the beta cell to adapt to changing metabolic demands that occur throughout life. Amongst these factors, Pdx1 plays a critical role in defining the region of the primitive gut… Expand
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References

SHOWING 1-10 OF 145 REFERENCES
Minireview: transcriptional regulation in pancreatic development.
TLDR
An understanding of the importance of transcription factor genes during pancreas development has provided insights into the pathogenesis of diabetes, in which the mass of insulin-producing beta-cells is reduced. Expand
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
TLDR
It is suggested that MafB may have a dual role in regulating embryonic differentiation of both beta- and alpha-cells while MafA may regulate replication/survival and function of beta-cells after birth. Expand
MafB is required for islet β cell maturation
TLDR
It is demonstrated that MafB plays a previously uncharacterized role by regulating transcription of key factors during development that are required for the production of mature α and β cells. Expand
Sox9 coordinates a transcriptional network in pancreatic progenitor cells
TLDR
It is indicated that Sox9 plays a dual role in pancreatic progenitor cells: both maintaining a stable transcriptional network and supporting the programs by which these cells differentiate into distinct lineages. Expand
The FoxM1 Transcription Factor Is Required to Maintain Pancreatic β-Cell Mass
TLDR
It is found that FoxM1 is highly expressed in embryonic and neonatal endocrine cells, when many of these cells are proliferating, and functions similarly in embryonic outgrowth of the pancreas and β-cell proliferation in the adult. Expand
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.
TLDR
Ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types, and it is shown that ngn3-positive cells coexpress neither insulin nor glucagon, suggesting thatngn3 marks early precursors of pancreaticendocrine cells. Expand
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the α- and β-cell lineages in the mouse endocrine pancreas
TLDR
The findings reveal a so far unrecognized essential role of the paired-box-encoding Pax4 gene and provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation. Expand
Transcriptional networks controlling pancreatic development and beta cell function
TLDR
It is proposed that pancreatic gene programs might be manipulated to generate beta cells or to enhance the function of existing beta cells, thereby providing a possible treatment of different forms of diabetes. Expand
Regulation of the pancreatic pro-endocrine gene neurogenin3.
TLDR
A model in which the ngn3 gene is activated by the coordinated activities of several pancreatic transcription factors and inhibited by Notch signaling through HES1 is suggested, which suggests that the addition of distal sequences greatly enhances transgene expression. Expand
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.
TLDR
Calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes. Expand
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