Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

  title={Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell},
  author={A. S. Bernardo and C. Hay and K. Docherty},
  journal={Molecular and Cellular Endocrinology},
  • A. S. Bernardo, C. Hay, K. Docherty
  • Published 2008
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • In recent years major progress has been made in understanding the role of transcription factors in the development of the endocrine pancreas in the mouse. Here we describe how a number of these transcription factors play a role in maintaining the differentiated phenotype of the beta cell, and in the mechanisms that allow the beta cell to adapt to changing metabolic demands that occur throughout life. Amongst these factors, Pdx1 plays a critical role in defining the region of the primitive gut… CONTINUE READING
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