Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

@article{Lonardo2012PancreaticSC,
  title={Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.},
  author={Enza Lonardo and Javier Frias-Aldeguer and Patrick C. Hermann and Christopher Heeschen},
  journal={Cell cycle},
  year={2012},
  volume={11 7},
  pages={1282-90}
}
Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are characterized by extensive fibrosis. Importantly, in PDAC, this results in poor vascularization and impaired drug delivery to the cancer cells. Therefore, the combined targeting of pancreatic tumor stroma and chemotherapy should enhance response rates, but the negative outcome of a recent phase III clinical trial for the combination of chemotherapy and hedgehog pathway inhibition suggests that other means also need to be… CONTINUE READING