Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis.

@article{Apte1999PancreaticSC,
  title={Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis.},
  author={Minoti Vivek Apte and Paul S Haber and Steve Darby and Seth Rodgers and Geoffrey W Mccaughan and Mark Allen Korsten and Romano Cesare Pirola and Jeremy Somers Wilson},
  journal={Gut},
  year={1999},
  volume={44 4},
  pages={534-41}
}
BACKGROUND The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells play a major role in fibrogenesis by synthesising increased amounts of collagen and other extracellular matrix (ECM) proteins when activated by profibrogenic mediators such as cytokines and oxidant stress. AIMS To determine whether cultured rat pancreatic stellate cells produce collagen and other ECM proteins, and exhibit signs of activation when exposed to the cytokines platelet derived growth factor… CONTINUE READING
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