Pancreatic stellate cells: partners in crime with pancreatic cancer cells.

  title={Pancreatic stellate cells: partners in crime with pancreatic cancer cells.},
  author={Alain Vonlaufen and Swapna Joshi and Changfa Qu and Phoebe A. Phillips and Zhihong Xu and Nicole Parker and Cheryl Sam Toi and Romano Cesare Pirola and Jeremy Somers Wilson and David Goldstein and Minoti Vivek Apte},
  journal={Cancer research},
  volume={68 7},
Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell lines MiaPaCa-2 and Panc-1. Athymic mice received an intrapancreatic injection of saline, hPSCs, MiaPaCa-2 cells, or hPSCs + MiaPaCa-2. After 7 weeks, tumor size, metastases… CONTINUE READING
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