Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba

@article{Bustanji2011PancreaticLI,
  title={Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba},
  author={Yasser K. Bustanji and Ihab M. Al-masri and Mohammad Khalil Mohammad and Mohammad M. Hudaib and Khaled A. Tawaha and Hamada Tarazi and Hatim S Alkhatib},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  year={2011},
  volume={26},
  pages={453 - 459}
}
The prevalence of obesity is increasing at an alarming rate, but, unfortunately, only a few drugs are currently available on the market. In the present study, the methanolic extract of Ginkgo biloba L. (Ginkgoaceae) was investigated as an inhibitor of pancreatic lipase (PL) in an attempt to explain its hypolipidaemic activity. In vitro assay of G. biloba leaves extract revealed a substantial PL inhibition activity (IC50 = 16.5 µg/mL). Further investigation was performed by employing theoretical… Expand
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