Pancreatic islet transplantation: Immuno-alteration with ultraviolet irradiation

  title={Pancreatic islet transplantation: Immuno-alteration with ultraviolet irradiation},
  author={Mark Adam Hardy and H. T. Lau and Collin Weber and Keith Reemtsma},
  journal={World Journal of Surgery},
To circumvent rejection of allogeneic pancreatic islet grafts, we have examined the use of ultraviolet (UV) irradiation to inactivate allostimulatory cells in blood prior to their use for the induction of donor-specific tolerance and to decrease the immunogenicity of pancreatic islets by direct UV irradiation. UVB (280–320 nm) irradiation of blood can effectively abrogate lymphocyte stimulatory capacity in an MLC, while subsequent transfusions of appropriately UV irradiated blood have… CONTINUE READING
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1 Excerpt

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