Pancreatic islet-specific T-cell clones from nonobese diabetic mice.


We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. In vivo, the clones mediate the destruction of islet, but not pituitary, grafts. Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients.

5 Figures and Tables

Citations per Year

1,406 Citations

Semantic Scholar estimates that this publication has 1,406 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Haskins1989PancreaticIT, title={Pancreatic islet-specific T-cell clones from nonobese diabetic mice.}, author={Kathryn M. Haskins and Mercedes Portas and Bryan Bergman and Kelsey Lafferty and Brenda J. Bradley}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1989}, volume={86 20}, pages={8000-4} }