Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

Abstract

We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. In vivo, the clones mediate the destruction of islet, but not pituitary, grafts. Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients.

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@article{Haskins1989PancreaticIT, title={Pancreatic islet-specific T-cell clones from nonobese diabetic mice.}, author={Kathryn M. Haskins and Mercedes Portas and Bryan Bergman and Kelsey Lafferty and Brenda J. Bradley}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1989}, volume={86 20}, pages={8000-4} }