Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants

  title={Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants},
  author={Lorenzo Pasquali and Kyle J. Gaulton and Santiago A. Rodr{\'i}guez-Segu{\'i} and Loris Mularoni and Irene Miguel-Escalada and Ildem Akerman and Juan J. Tena and Ignasi Moran and Carlos G{\'o}mez-Mar{\'i}n and Martijn van de Bunt and Joan Ponsa-Cobas and Natalia Castro and Takao Nammo and In{\^e}s Cebola and Javier Garc{\'i}a-Hurtado and Miguel A Maestro and François Pattou and Lorenzo Piemonti and Thierry Berney and Anna L Gloyn and Philippe Ravassard and Jos{\'e} Luis G{\'o}mez Skarmeta and Ferenc M{\"u}ller and Mark I. McCarthy and Jorge Ferrer},
  booktitle={Nature Genetics},
Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regulation could therefore provide valuable mechanistic insights. We have now mapped and examined the function of human islet cis-regulatory networks. We identify genomic sequences that are targeted by islet transcription factors to… CONTINUE READING
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