Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.

@article{Gremlich2005PancreaticIA,
  title={Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.},
  author={Sandrine Gremlich and Christopher Nolan and Rapha{\"e}l Roduit and Remy Burcelin and Marie-Line Peyot and Viviane Delghingaro-Augusto and B{\'e}atrice Desvergne and Liliane Michalik and Marc Prentki and Walter Wahli},
  journal={Endocrinology},
  year={2005},
  volume={146 1},
  pages={375-82}
}
The cellular response to fasting and starvation in tissues such as heart, skeletal muscle, and liver requires peroxisome proliferator-activated receptor-alpha (PPARalpha)-dependent up-regulation of energy metabolism toward fatty acid oxidation (FAO). PPARalpha null (PPARalphaKO) mice develop hyperinsulinemic hypoglycemia in the fasting state, and we previously showed that PPARalpha expression is increased in islets at low glucose. On this basis, we hypothesized that enhanced PPARalpha… CONTINUE READING

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