Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.

@article{Matsui2009PancreaticFO,
  title={Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.},
  author={Kenichi Matsui and Tomohiro Oda and Emiko Nishizawa and Ryuhei Sano and Hiromi Yamamoto and Sumiaki Fukuda and Tomohiko Sasase and Katsuhiro Miyajima and Nobuhisa Ueda and Yukihito Ishii and Takeshi Ohta and Mutsuyoshi Matsushita},
  journal={Experimental animals},
  year={2009},
  volume={58 4},
  pages={
          363-74
        }
}
The Spontaneously Diabetic Torii (SDT) rat is a new model for non-obese type 2 diabetes. In the present study, we investigated changes in insulin secretion from the pancreas of male SDT rats aged 8, 16, and 24 weeks in order to analyze pancreatic function. An analysis of glucose-stimulated insulin secretion (GSIS) in isolated islets showed a marked reduction in insulin secretion in pre-diabetic 16-week-old SDT rats. When the islets were treated with tolbutamide or glucagon-like peptide-1 (7-36… 

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References

SHOWING 1-10 OF 32 REFERENCES

Preventive effects of glycaemic control on ocular complications of Spontaneously Diabetic Torii rat

Aim:  Spontaneously Diabetic Torii (SDT) rat is a new model of non‐obese type 2 diabetes. SDT rats show severe ocular complications such as cataracts, tractional retinal detachment with fibrous

Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats.

The features of spontaneously diabetic Torii (SDT) rats indicate their usefulness as an animal model for investigating diabetic nephropathy and Glycemic control in SDT rats prevented the development of renal lesions.

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

It is suggested that changes in the normal pattern of gene expression contribute to the development of β-cell dysfunction, and genes that play a key role in regulating insulin secretion and, thus, may be potential targets for therapeutic intervention aimed at preserving or improving β- cell function are identified.

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

It is suggested that changes in the normal pattern of gene expression contribute to the development of beta-cell dysfunction, and genes that play a key role in regulating insulin secretion and, thus, may be potential targets for therapeutic intervention aimed at preserving or improving beta- cell function are identified.

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity.

It is proposed that chronic hyperglycemia, independent of hyperlipidemia, is toxic for beta-cell function, whereas chronic hyper Lipotoxicity is deleterious only in the context of concomitant hyper glycemia.

Effects of S 15511, a therapeutic metabolite of the insulin‐sensitizing agent S 15261, in the Zucker Diabetic Fatty rat

This study was designed to determine the biological activity of S 15261 and its two major metabolites, S 15511 and Y 415, and whether or not they have an additive effect.

Insulin Secretory Defect in Zucker fa/fa Rats Is Improved by Ameliorating Insulin Resistance

The data indicate that ameliorating insulin resistance reverses defective glucosestimulated insulin release by Zucker fa/fa rats and may be augmented by increased generation of a metabolic coupling factor from glucose or at a later step in the secretory process that is common to both glucose and nonglucose secretagogues.

Development of glucose intolerance in obese (fa/fa) Zucker rats.

  • R. ApweilerP. Freund
  • Biology, Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 1993
It is concluded that glucose intolerance and insulin resistance in genetically obese (fa/fa) rats is almost completely developed with approximately 12 weeks.

JTT‐608 restores impaired early insulin secretion in diabetic Goto‐Kakizaki rats

It is concluded that in diabetic GK rats JTT‐608 suppressed postprandial glucose excursions with enhanced glucose‐stimulated insulin secretion, especially the first phase of insulin secretion.

Insulin Responses in Equivocal and Definite Diabetes, with Special Reference to Subjects Who Had Mild Glucose Intolerance but Later Developed Definite Diabetes

The decrease in insulin response to glucose seems to be a more Inherent, specific, and stable feature of true diabetes than glucose intolerance, because it precedes the occurrence and persists after the remission of derangement of carbohydrate metabolism in definite diabetes.