Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.

  title={Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.},
  author={Kenichi Matsui and T. Oda and E. Nishizawa and Ryuhei Sano and H. Yamamoto and S. Fukuda and T. Sasase and K. Miyajima and N. Ueda and Y. Ishii and T. Ohta and M. Matsushita},
  journal={Experimental animals},
  volume={58 4},
  • Kenichi Matsui, T. Oda, +9 authors M. Matsushita
  • Published 2009
  • Medicine
  • Experimental animals
  • The Spontaneously Diabetic Torii (SDT) rat is a new model for non-obese type 2 diabetes. In the present study, we investigated changes in insulin secretion from the pancreas of male SDT rats aged 8, 16, and 24 weeks in order to analyze pancreatic function. An analysis of glucose-stimulated insulin secretion (GSIS) in isolated islets showed a marked reduction in insulin secretion in pre-diabetic 16-week-old SDT rats. When the islets were treated with tolbutamide or glucagon-like peptide-1 (7-36… CONTINUE READING
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