Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK.

@article{Lacourse1999PancreaticFI,
  title={Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK.},
  author={Karen A Lacourse and Lisa J Swanberg and Patrick J. Gillespie and Jens Frederik Rehfeld and Thomas L Saunders and Linda C. Samuelson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1999},
  volume={276 5},
  pages={G1302-G1309}
}
A CCK-deficient mouse mutant generated by gene targeting in embryonic stem cells was analyzed to determine the importance of CCK for growth and function of the exocrine pancreas and for pancreatic adaptation to dietary changes. RIAs confirmed the absence of CCK in mutant mice and demonstrated that tissue concentrations of the related peptide gastrin were normal. CCK-deficient mice are viable and fertile and exhibit normal body weight. Pancreas weight and cellular morphology appeared normal… CONTINUE READING

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Impaired gastric acid secretion in gastrin-deficient mice.

American journal of physiology. Gastrointestinal and liver physiology • 1998
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