Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

@article{Kroon2008PancreaticED,
  title={Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo},
  author={Evert Kroon and Laura A. Martinson and Kuniko Kadoya and Anne G Bang and Olivia G. Kelly and Susan Eliazer and Holly Young and Mike Richardson and Nora G. Smart and Justine J Cunningham and Alan D. Agulnick and Kevin A. D'Amour and Melissa K. Carpenter and Emmanuel E. Baetge},
  journal={Nature Biotechnology},
  year={2008},
  volume={26},
  pages={443-452}
}
Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from human embryonic stem (hES) cells efficiently generates glucose-responsive endocrine cells after implantation into mice. Upon glucose stimulation of the implanted mice, human insulin and C-peptide are detected in sera at levels similar to those of mice transplanted with ∼3,000 human islets. Moreover, the insulin-expressing cells generated… CONTINUE READING
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