Pancreatic endocrine tumor with signet ring cell features: a case report with novel ultrastructural observations.

@article{Stokes1998PancreaticET,
  title={Pancreatic endocrine tumor with signet ring cell features: a case report with novel ultrastructural observations.},
  author={Michael B Stokes and Ajaya Kumar and W. Fraser Symmans and John V. Scholes and Jonathan Melamed},
  journal={Ultrastructural pathology},
  year={1998},
  volume={22 2},
  pages={147-52}
}
The case of a malignant pancreatic endocrine neoplasm with an unusual signet ring cell appearance is reported. The tumor was resected from a 30-year-old man with a 4.0-cm tumor in the body of the pancreas diagnosed by computerized tomographic (CT) scan. The resected tumor had a unique morphology characterized by numerous mucin-negative, signet ring cells, which were argyrophilic and immunoreactive for cytokeratin (CAM 5.2), chromogranin, synaptophysin, neuron specific enolase, and gastrin… CONTINUE READING