Pancreatic carcinoma in azaserine-treated rats: induction, classification and dietary modulation of incidence.

@article{Longnecker1981PancreaticCI,
  title={Pancreatic carcinoma in azaserine-treated rats: induction, classification and dietary modulation of incidence.},
  author={Daniel S. Longnecker and Bill D. Roebuck and James D. Yager and H S Lilja and bertrand. siegmund},
  journal={Cancer},
  year={1981},
  volume={47 6 Suppl},
  pages={1562-72}
}
Pancreatic carcinomas have been induced in Wistar and W/LEW rats by administration of total azaserine doses of 150-520 mg/kg by injection or oral routes over periods of 5-52 weeks. The latent period for development of invasive carcinomas was 1-2 years, but focal abnormalities in acinar cells appear earlier. The incidence of carcinomas varied with total dose, route, and schedule of azaserine administration. The spectrum of histologic patterns of the carcinomas included well and poorly… CONTINUE READING

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