Pancreatic carcinogenesis: effect of secretin in the hamster- nitrosamine model.

@article{Howatson1987PancreaticCE,
  title={Pancreatic carcinogenesis: effect of secretin in the hamster- nitrosamine model.},
  author={Allan G. Howatson and D. Camille Carter},
  journal={Journal of the National Cancer Institute},
  year={1987},
  volume={78 1},
  pages={101-5}
}
The effect of exogenous secretin on pancreatic carcinogenesis in WO strain hamsters has been examined in the nitrosamine-ductular adenocarcinoma model. Secretin, 20 clinical U/kg, stimulated a maximal secretory response of pancreatic juice and bicarbonate when given iv. The same dose given sc for 6 weeks had no significant effect on pancreatic wet weight and DNA or RNA contents. However, when given to animals receiving N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4] (5 mg/kg), it reduced… CONTINUE READING

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