Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway.

@article{Yoshida2004PancreaticCS,
  title={Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway.},
  author={Seiya Yoshida and Tokuyasu Yokota and Michael Ujiki and X. Ding and Carolyn A. Pelham and Thomas Edward Adrian and Mark S. Talamonti and Richard H. Bell and Woody Denham},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={323 4},
  pages={1241-5}
}
Pancreatic adenocarcinoma is characterized by an intense desmoplastic reaction that surrounds the tumor. Pancreatic stellate cells (PSCs) are thought to be responsible for production of this extracellular matrix. When activated, PSCs have a myofibroblast phenotype and produce not only components of the extracellular matrix including collagen, fibronectin, and laminin, but also matrix metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs). Since PSCs are found in the stroma… CONTINUE READING

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