Pancreatic cancer regression by intratumoural injection of live Streptococcus pyogenes in a syngeneic mouse model.

@article{Maletzki2008PancreaticCR,
  title={Pancreatic cancer regression by intratumoural injection of live Streptococcus pyogenes in a syngeneic mouse model.},
  author={Claudia Maletzki and Michael Linnebacher and Bernd Kreikemeyer and J{\~o}rg Emmrich},
  journal={Gut},
  year={2008},
  volume={57 4},
  pages={483-91}
}
BACKGROUND This study addressed the potential of bacteriolytic therapy using Streptococcus pyogenes in a syngeneic pancreatic carcinoma mouse model. METHODS Panc02 tumours were either infected with S pyogenes or were treated with the equivalent volume of vehicle. In addition to assessment of tumour histology and immunohistochemistry, isolated splenocytes were analysed by flow cytometry. Interferon (IFN) gamma secretion as a reaction of splenocytes against tumour cells was shown through the… CONTINUE READING
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