Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

  title={Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver},
  author={Bruno Costa-Silva and Nicole M. Aiello and Allyson J. Ocean and Swarnima Singh and Haiying Zhang and Basant Kumar Thakur and Annette Becker and Ayuko Hoshino and Milica Te{\vs}i{\'c} Mark and Henrik Molina and Jenny Xiang and Tuo Zhang and T M Theilen and Guillermo Garc{\'i}a-Santos and Caitlin J Williams and Yonathan Tarekegne Ararso and Yujie Huang and Gonçalo Rodrigues and Tang-Long Shen and Knut J\orgen Labori and Inger Marie Bowitz Lothe and Elin H. Kure and Jonathan Hernandez and Alexandre Doussot and Saya H. Ebbesen and Paul M. Grandgenett and Michael Anthony Hollingsworth and Maneesh Jain and Kavita B Mallya and Surinder K Batra and William R. Jarnagin and Robert E. Schwartz and Irina R. Matei and H{\'e}ctor Peinado and Ben Z. Stanger and Jacqueline Bromberg and David Lyden},
  journal={Nature Cell Biology},
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden. Uptake of PDAC-derived exosomes by Kupffer cells caused transforming growth factor β secretion and upregulation of fibronectin production by… CONTINUE READING
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