Pancreatic cancer cells surviving gemcitabine treatment express markers of stem cell differentiation and epithelial-mesenchymal transition.

@article{Quint2012PancreaticCC,
  title={Pancreatic cancer cells surviving gemcitabine treatment express markers of stem cell differentiation and epithelial-mesenchymal transition.},
  author={K. R. Quint and Manuel Tonigold and Pietro Di Fazio and Roberta Montalbano and Susanne Lingelbach and Felix Rueckert and Beate Alinger and Matthias Ocker and Daniel Neureiter},
  journal={International journal of oncology},
  year={2012},
  volume={41 6},
  pages={2093-102}
}
Objective response rates to standard chemotherapeutic regimens remain low in pancreatic cancer. Subpopulations of cells have been identified in various solid tumors which express stem cell-associated markers and are associated with increased resistance against radiochemotherapy. We investigated the expression of stem cell genes and markers of epithelial-mesenchymal transition in pancreatic cancer cells that survived high concentrations of gemcitabine treatment. Capan-1 and Panc-1 cells were… CONTINUE READING
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