Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin.

@article{Ding1998PancreaticCC,
  title={Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin.},
  author={Xian Z Ding and Peter Raymond Flatt and Johan Permert and Thomas Edward Adrian},
  journal={Gastroenterology},
  year={1998},
  volume={114 1},
  pages={130-8}
}
BACKGROUND & AIMS Patients with pancreatic adenocarcinoma have a high incidence of diabetes, profound insulin resistance, and high circulating amylin concentrations. It was hypothesized that pancreatic cancer cells produce a factor that stimulates islets to secrete amylin but not insulin. METHODS Amylin and insulin secretion were measured after coculture of pancreatic cancer cells with beta cells (BRIN-BD11). The factor responsible was characterized by exposing beta cells to cancer cell… CONTINUE READING