Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand.

@article{Bernstorff1999PancreaticCC,
  title={Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand.},
  author={Wolfgang von Bernstorff and Remco A. Spanjaard and Anthony K C Chan and Daniel C Lockhart and Noriaki Sadanaga and Isabelle Wood and Matthias Peiper and Peter S. Goedegebuure and Timothy J. Eberlein},
  journal={Surgery},
  year={1999},
  volume={125 1},
  pages={73-84}
}
BACKGROUND The Fas (APO-1/CD95) receptor/Fas ligand (FasR/FasL) system plays a key role in immune surveillance. We investigated the possibility of a tumor escape mechanism involving the FasR/FasL system in pancreatic cancer cells. METHODS Fourteen pancreatic cancer cell lines and 3 pancreatic cancer surgical specimens were studied for their expression of FasR and FasL by flow cytometry, immunoblotting, and immunohistochemistry, FasR function was tested with an anti-FasR antibody. FasL… CONTINUE READING

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