Pancreatic cancer cachexia: a review of mechanisms and therapeutics

  title={Pancreatic cancer cachexia: a review of mechanisms and therapeutics},
  author={Carlyn Rose C Tan and Patrick M. Yaffee and Laith H. Jamil and Simon K F Lo and Nicholas N. Nissen and Stephen J Pandol and Richard Tuli and Andrew Eugene Hendifar},
  booktitle={Front. Physiol.},
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology… CONTINUE READING
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