Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.

Abstract

We have demonstrated that 3-phosphoinositide-dependent protein kinase 1 (PDK1) contributes to signaling by insulin or insulin-like growth factor-1 (IGF-1) that is responsible for the regulation of both the number and size of pancreatic beta cells in mice. Complete ablation of PDK1 in pancreatic beta cells leads to progressive hyperglycemia as a result of… (More)

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Cite this paper

@article{Takeda2008PancreaticBC, title={Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.}, author={A. L. Takeda and Yoshiaki Kido and Naoko Hashimoto and Tetsuo Noda and Masato Kasuga}, journal={The Kobe journal of medical sciences}, year={2008}, volume={54 3}, pages={E183-90} }