Pancreatic beta cell lines and their applications in diabetes mellitus research.

@article{Skelin2010PancreaticBC,
  title={Pancreatic beta cell lines and their applications in diabetes mellitus research.},
  author={Ma{\vs}a Skelin and Marjan Rupnik and Avrelija Cencic},
  journal={ALTEX},
  year={2010},
  volume={27 2},
  pages={105-13}
}
During the past 30 years great effort has been put into establishing an insulin-secreting beta cell line that retains normal regulation of insulin secretion, but only few of these attempts have been successful. To overcome the limited availability of primary beta cells and to include the principles of the 3Rs into the field of diabetes mellitus research, numerous investigators used X-rays or viruses to induce insulinomas, in vitro transformation, derivation of cells from transgenic mice or even… CONTINUE READING