Pancreatic beta-cell hyperactivity in morbidly obese adolescents.

  title={Pancreatic beta-cell hyperactivity in morbidly obese adolescents.},
  author={Arlene B. Mercado and Salvador Castells},
  journal={Pediatric endocrinology reviews : PER},
  volume={3 Suppl 4},
beta-cell hyperactivity, with increased beta-cell mass in the pancreas, contributes to insulin oversecretion in response to insulin resistance. beta-cell mass expansion, also known as "endocrine pancreas plasticity", is an adaptation to variations in insulin demand, is generally observed in obese persons and in women during late pregnancy. In obese persons, increased free fatty acids contribute to beta-cell growth. It is believed that type 2 diabetes develops in those persons unable to respond… CONTINUE READING