Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes.

@article{Harrison2004PancreaticBF,
  title={Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes.},
  author={Leonard C. Harrison and Margo C. Honeyman and Cheryl E Steele and Natalie L. Stone and Elena Sarugeri and Ezio Bonifacio and Jennifer J. Couper and Peter G. Colman},
  journal={Diabetes care},
  year={2004},
  volume={27 10},
  pages={2348-55}
}
OBJECTIVE Mucosal administration of insulin retards development of autoimmune diabetes in the nonobese diabetic mouse model. We conducted a double-blind crossover study in humans at risk for type 1 diabetes to determine if intranasal insulin was safe, in particular did not accelerate beta-cell destruction, and could induce immune effects consistent with mucosal tolerance. RESEARCH DESIGN AND METHODS A total of 38 individuals, median age 10.8 years, with antibodies to one or more pancreatic… CONTINUE READING
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