Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.

@article{Ladiges2005PancreaticBF,
  title={Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.},
  author={Warren C. Ladiges and Sue E. Knoblaugh and John Frederick Morton and Marcus J. Korth and Bryce L. Sopher and Carole R. Baskin and Alasdair MacAuley and Alan G Goodman and Ren{\'e}e C Leboeuf and Michael G. Katze},
  journal={Diabetes},
  year={2005},
  volume={54 4},
  pages={1074-81}
}
The endoplasmic reticulum (ER) transmits apoptotic signals in the pancreas during ER stress, implicating ER stress-mediated apoptosis in the development of diabetes. P58(IPK) (DNAJC3) is induced during ER stress and functions as a negative feedback component to inhibit eIF-2alpha signaling and attenuate the later phases of the ER stress response. To gain insight into a more comprehensive role of P58(IPK) function, we generated deletion mutant mice that showed a gradual onset of glucosuria and… CONTINUE READING
77 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

Similar Papers

Loading similar papers…