Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.

  title={Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.},
  author={Tehsina Devji and C Obula Reddy and Christina M Woo and Suresh Awale and Shigetoshi Kadota and Dora Carrico-Moniz},
  journal={Bioorganic & medicinal chemistry letters},
  volume={21 19},
A series of hydroxycoumarin derivatives has been synthesized and evaluated against human pancreatic PANC-1 cancer cells under nutrient-deprived conditions. Several compounds exhibited 100% preferential cytotoxicity at low micromolar concentrations under nutrition starvation, and showed no cytotoxicity under nutrient-rich conditions. In this study, a novel geranylgeranylated ether coumarin derivative 9 was found to exhibit the highest cytotoxic activity of 6.25 μM within 24h. The preferential… CONTINUE READING

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