Pancreatic and extrapancreatic sulfonylurea receptors.

@article{Panten1992PancreaticAE,
  title={Pancreatic and extrapancreatic sulfonylurea receptors.},
  author={Uwe Panten and Mathias Schwanstecher and Christina Schwanstecher},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={1992},
  volume={24 12},
  pages={549-54}
}
The hypoglycemic effect of sulfonylureas and their analogues results from their binding to a high affinity site in the B-cell plasma membrane. This site seems to be a structural component of the ATP-sensitive K(+)-channel and represents the pancreatic sulfonylurea receptor. Binding of sulfonylureas causes closure of the ATP-sensitive K(+)-channel and thereby initiates a chain of events eventually leading to the release of insulin. Diazoxide inhibits insulin secretion via opening of the ATP… CONTINUE READING