Pancreatic Neuroendocrine Tumors in Glucagon Receptor-Deficient Mice

@inproceedings{Yu2011PancreaticNT,
  title={Pancreatic Neuroendocrine Tumors in Glucagon Receptor-Deficient Mice},
  author={Run Yu and Deepti Dhall and Nicholas N. Nissen and Cuiqi Zhou and Song-guang Ren},
  booktitle={PloS one},
  year={2011}
}
Inhibition of glucagon signaling causes hyperglucagonemia and pancreatic α cell hyperplasia in mice. We have recently demonstrated that a patient with an inactivating glucagon receptor mutation (P86S) also exhibits hyperglucagonemia and pancreatic α cell hyperplasia but further develops pancreatic neuroendocrine tumors (PNETs). To test the hypothesis that defective glucagon signaling causes PNETs, we studied the pancreata of mice deficient in glucagon receptor (Gcgr(-/-)) from 2 to 12 months… CONTINUE READING
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