Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators

@article{Brandhorst2016PancreaticLA,
  title={Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators},
  author={H. Brandhorst and B. Theisinger and B. Guenther and P. Johnson and D. Brandhorst},
  journal={Cell Transplantation},
  year={2016},
  volume={25},
  pages={531 - 538}
}
The isolation and transplantation of porcine islets represent a future option for the treatment of type 1 diabetic patients. Stringent product release criteria and limited availability of transgenic and specific pathogen-free pigs will essentially require processing of explanted pig pancreata in specialized, possibly remote isolation facilities, whereby pancreata are exposed to cold ischemia due to prolonged tissue transit time. In the present study we investigated whether pancreas oxygenation… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Intra‐Ductal Glutamine Administration Reduces Oxidative Injury During Human Pancreatic Islet Isolation
  • J. Avila, B. Barbaro, +9 authors J. Oberholzer
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2005
Short-Term Storage of the Ischemically Damaged Human Pancreas by the Two-Layer Method Prior to Islet Isolation
A New Oxygen Carrier for Improved Long-Term Storage of Human Pancreata Before Islet Isolation
Perfluorohexyloctane improves long‐term storage of rat pancreata for subsequent islet isolation
Islet xenotransplantation from genetically engineered pigs
...
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2
3
4
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