Pancreatic Extracts in The Treatment of Diabetes Mellitus

  title={Pancreatic Extracts in The Treatment of Diabetes Mellitus},
  author={Frederick Grant Banting and Charles Herbert Best and J. B. Collip and Walter R. Campbell and A. Almon Fletcher},
  pages={69 - 71}
Since the year 1889, when von Mering and Minkowski produced severe and fatal diabetes by total removal of the pancreas in dogs, many investigators have endeavoured to obtain some beneficial effect in diabetes mellitus, either by feeding pancreas, or by administration of pancreatic extracts. 
Diabetes Its Medical and Cultural History
This study deals with knowledge of the pancreas from the 17th to the 19th centuries: the investigations of Brunner in 1689 were a landmark and another culminating point was the tissue system described by Bichat in 1800.
Insulin Pharmacotherapy
Direct evidence for this function came in 1889, when Oskar Minkowski and Joseph von Mering showed that pancreatectomized dogs exhibit a syndrome similar to diabetes mellitus in humans.
The Endocrine Pancreas
Although the systematic collection of information on the endocrine pancreas dates from the anatomical description of the islets of Langerhans, much had previously been learned about diabetes by the
A case of diabetes mellitus.
A 27-year-old diabetic man was admitted to the Toronto General Hospital in severe ketoacidosis after five days of nausea and vomiting. The patient had had diabetes mellitus for 15 years and had bee...
The History of Insulin
Supporting evidence for the hypothesis gradually mounted, including observations of the relationship between diabetes and damage to the pancreatic cellular system known as the islets of Langerhans, as well as the discovery and elucidation of the physiology of internal or endocrine secretions.
Revisiting the Pharmacological Value of Glucagon: An Editorial for the Special Issue “The Biology and Pharmacology of Glucagon”
In 1921, a Canadian research team led by Frederick Banting and John Macleod succeeded in the isolation of insulin from pancreatic homogenate [...].
The first successful therapeutic use of pancreas extracts of bovine insulin occurred at the Toronto General Hospital on January 11, 1922, on a 14-year-old patient, Leonard Thompson, who was admitted with type 1 diabetes, and completely revolutionized diabetes therapy.