Pancreatic Cancer as a Model: Inflammatory Mediators, Acute-phase Response, and Cancer Cachexia

@article{Fearon1999PancreaticCA,
  title={Pancreatic Cancer as a Model: Inflammatory Mediators, Acute-phase Response, and Cancer Cachexia},
  author={Kenneth C. H. Fearon and Matthew D Barber and J. Stuart Falconer and Donald Calum McMillan and Jr James Alexander Ross and Tom Preston},
  journal={World Journal of Surgery},
  year={1999},
  volume={23},
  pages={584-588}
}
Abstract. Patients with pancreatic cancer frequently develop the syndrome of cancer cachexia. Pro-inflammatory cytokines have been strongly implicated in the pathogenesis of this syndrome. In patients with pancreatic cancer an acute-phase response (an index of pro-inflammatory cytokine activity) is associated with accelerated weight loss, hypermetabolism, anorexia, and a shortened duration of survival. However, little is known about the primary significance of the acute-phase response in terms… CONTINUE READING
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