Pancreatic Cancer

  title={Pancreatic Cancer},
  author={Jorg Kleeff and Murray Korc and Minoti Vivek Apte and Carlo L A Vecchia and C Douglas Johnson and Andrew V. Biankin and Rachel E. Neale and Margaret A. Tempero and David A. Tuveson and Ralph H. Hruban and John P Neoptolemos},
  journal={Nature Reviews Disease Primers},
Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall prognosis that has remained virtually unchanged for many decades. Currently, prevention or early diagnosis at a curable stage is exceedingly difficult; patients rarely exhibit symptoms and tumours do not display sensitive and specific markers to aid detection. Pancreatic cancers also have few prevalent genetic mutations; the most commonly mutated genes are KRAS, CDKN2A (encoding p16), TP53 and SMAD4 — none… CONTINUE READING