Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation

  title={Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation},
  author={Esteban N Gurzov and Jenny Barthson and Ihsane Marhfour and Fernanda Ortis and Najib Naamane and Mariana Igoillo-Esteve and Conny A. Gysemans and C{\'e}line Mathieu and Shojiro Kitajima and Philippe Marchetti and Torben F. \Orntoft and Latifa Bakiri and Erwin F Wagner and Decio L. Eizirik},
Destruction of insulin-producing pancreatic β-cells by local autoimmune inflammation is a hallmark of type 1 diabetes. Histochemical analysis of pancreases from non-obese diabetic mice indicated activation of the transcription factor JunB/AP-1 (activator protein-1) after autoimmune infiltration of the islets. In vitro studies demonstrated that the cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-γ induce JunB expression as a protective mechanism against apoptosis in both human and… CONTINUE READING


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