Pancreatic β-cell regeneration: Facultative or dedicated progenitors?

  title={Pancreatic β-cell regeneration: Facultative or dedicated progenitors?},
  author={Solomon Afelik and M. Rovira},
  journal={Molecular and Cellular Endocrinology},
  • Solomon Afelik, M. Rovira
  • Published 2017
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The adult pancreas is only capable of limited regeneration. Unlike highly regenerative tissues such as the skin, intestinal crypts and hematopoietic system, no dedicated adult stem cells or stem cell niche have so far been identified within the adult pancreas. New β cells have been shown to form in the adult pancreas, in response to high physiological demand or experimental β-cell ablation, mostly by replication of existing β cells. The possibility that new β cells are formed from other sources… CONTINUE READING
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