Pancreatic β-cell regeneration: Facultative or dedicated progenitors?

@article{Afelik2017PancreaticR,
  title={Pancreatic $\beta$-cell regeneration: Facultative or dedicated progenitors?},
  author={Solomon Afelik and Meritxell Rovira},
  journal={Molecular and Cellular Endocrinology},
  year={2017},
  volume={445},
  pages={85-94}
}
Pancreatic b-cell replacement: advances in protocols used for differentiation of pancreatic progenitors to b-like cells
TLDR
Some of the state-of-the-art protocols for the differentiation of pancreatic progenitors and differentiated pancreatic cells into b-like cells are reviewed with a focus on pancreatic duct cells.
Generation of Human Stem Cell-Derived Pancreatic Organoids (POs) for Regenerative Medicine.
TLDR
The current knowledge on bioengineered POs and the stem cell differentiation platforms is summarized and the most relevant hurdles met to move towards clinical application are revised.
The Potential of Pancreatic Organoids for Diabetes Research and Therapy
TLDR
The attempts over the past decade to utilize the organoid cell culture principles in order to identify, expand, and differentiate the adult pancreatic stem cells from different compartments of mouse and human pancreata are reviewed.
Pancreatic β‐cell regeneration: From molecular mechanisms to therapy
TLDR
Different therapeutic approaches which could be used for the regeneration of pancreatic β cells are highlighted and used as potential therapies in the treatment of insulin‐dependent diabetes mellitus are highlighted.
Human Multipotent Stromal Cell Secreted Effectors Accelerate Islet Regeneration
TLDR
It is demonstrated that intrapancreatic‐injection of concentrated hMSC‐conditioned media (CM) stimulated islet regeneration without requiring cell transfer, and may lead to the development of cell‐free regenerative therapies able to tip the balance in favor of β‐cell regeneration versus destruction during diabetes.
Ductal Cell Reprogramming to Insulin-Producing Beta-Like Cells as a Potential Beta Cell Replacement Source for Chronic Pancreatitis.
TLDR
An overview of recent reports that demonstrate the potential of utilizing pancreatic ductal cells (PDCs) for reprogramming into insulin- producing cells is presented, focusing on the recent advances and the conflicting views.
Regenerating β cells of the pancreas – potential developments in diabetes treatment
TLDR
The mechanisms underlying embryonic β cell development and spontaneous adultβ cell regeneration form the basis for developing β cell regeneration strategies, and more hurdles need to be overcome before any of the strategies suggested can be fully translated from bench to bedside.
Regenerative Medicine for Diabetes Treatment: New β-Cell Sources
TLDR
This chapter discusses current knowledge and future perspectives on the replenishment of the β cell population in diabetic patients by induction of endogenous regeneration or by replacement with substitute β cells generated ex vivo.
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Additional evidence is presented that endocrine cells do not arise from ducts following b-cell ablation by streptozotocin or by a diphtheria toxin-expressing transgene or when b- cell ablation is combined with PDL.
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
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This work introduces a method for genetic lineage tracing to determine the contribution of stem cells to a tissue of interest and suggests that terminally differentiated β-cells retain a significant proliferative capacity in vivo and casts doubt on the idea that adult stem cells have a significant role in β-cell replenishment.
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TLDR
β-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total β-cell ablation is shown, revealing a previously disregarded degree of pancreatic cell plasticity.
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TLDR
It is shown that CAII-expressing cells within the pancreas act as progenitors that give rise to both new islets and acini normally after birth and after injury (ductal ligation).
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