Pancreatic β-cell identity, glucose sensing and the control of insulin secretion.

@article{Rutter2015PancreaticI,
  title={Pancreatic $\beta$-cell identity, glucose sensing and the control of insulin secretion.},
  author={G. Rutter and T. Pullen and D. Hodson and Aida Martinez-S{\'a}nchez},
  journal={The Biochemical journal},
  year={2015},
  volume={466 2},
  pages={
          203-18
        }
}
Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion underlies all forms of diabetes mellitus, a disease currently reaching epidemic proportions worldwide. Although the destruction of β-cells is responsible for Type 1 diabetes (T1D), both lowered β-cell mass and loss of secretory function are implicated in Type 2 diabetes (T2D). Emerging results suggest that a functional deficiency, involving de… Expand
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