Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin.

  title={Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin.},
  author={Caroline Korsten Messer and Raymond C. Boston and Derek Leroith and E. Buckley – Geer and Joshua D Miller and M P Messer and Walter Futterweit},
  journal={Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists},
  volume={18 5},
OBJECTIVE To determine whether the administration of 6 months of daily metformin treatment in women with polycystic ovary syndrome (PCOS) would significantly improve pancreatic β-cell function as measured by an increase in the disposition index. METHODS We enrolled women with PCOS from a private practice and from the Mount Sinai Hospital Endocrinology Clinic. All patients underwent frequently sampled intravenous glucose tolerance tests both on and off 500 to 1000 mg of twice daily metformin… CONTINUE READING
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