Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia

@article{Bennett2010PancreaticK,
  title={Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia},
  author={Kate Mary Bennett and Commissioner James and K. M. Iqbal Hussain},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2010},
  volume={11},
  pages={157-163}
}
The pancreatic β-cell ATP-sensitive K+ channel (KATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellular ratio of ATP/ADP mediate the metabolic regulation of channel activity. The β-cell KATP channel is a hetero-octameric complex composed of two types of subunits: four inward-rectifying potassium channel pore-forming (Kir6.2) subunits and four high-affinity sulfonylurea receptor 1… CONTINUE READING
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