Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A

@inproceedings{Song2013PancreaticR,
  title={Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A},
  author={Woo-jin Song and Prosenjit Mondal and Yuanyuan Li and Suh Eun Lee and Mehboob Ali Hussain},
  booktitle={Diabetes},
  year={2013}
}
Incretin hormone action on β-cells stimulates in parallel two different intracellular cyclic AMP-dependent signaling branches mediated by protein kinase A and exchange protein activated by cAMP islet/brain isoform 2A (EPAC2A). Both pathways contribute toward potentiation of glucose-stimulated insulin secretion (GSIS). However, the overall functional role of EPAC2A in β-cells as it relates to in vivo glucose homeostasis remains incompletely understood. Therefore, we have examined in vivo GSIS in… CONTINUE READING
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cAMP signalling in insulin and glucagon secretion.

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