Pancreas transplantation

  title={Pancreas transplantation},
  author={Patrick G. Dean and Aleksandra Kukla and Mark D Stegall and Yogish C. Kudva},
  journal={British Medical Journal},
The treatment of patients with diabetes mellitus (DM) presents many challenges to care providers and represents a major proportion of healthcare expenditure worldwide. Successful pancreas transplantation provides durable glycemic control and improves survival for patients with diabetes. Progress in the field has mainly been based on large single center studies and the cumulative analyses of registry data from the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant… 
Pancreatic transplantation: Brief review of the current evidence
This work will provide a simplified, yet up-to-date information regarding the different management options for those diabetic chronic kidney failure patients and have the best long term outcome in diabetic cases with renal failure.
The Current State of Pancreas Transplantation in the USA—A Registry Report
Outcome after pancreas transplantation has significantly improved due to refinement in immunosuppressive protocols and better donor and recipient selection, and will not only improve the quality of life of the patient but also can be life extending.
Donor insulin therapy in intensive care predicts early outcomes after pancreas transplantation
Donor insulin characteristics remained significant predictors of lower risk of graft thrombosis in pancreas transplant alone/pancreas after kidney transplant recipients and a significant improvement in discrimination and risk reclassification was observed in all models.
Difficult Situation of Pancreas Transplantation in the Setting of Scarce Organ Donation.
Transplantation technologies for treatment of carbohydrate metabolism disorders
The review includes results of retrospective and prospective clinical studies, guidelines on the use of transplantation technologies for treatment of type 1 diabetes and pancreatogenic diabetes in chronic pancreatitis and pancreatic conditions, and analysis of the technology for isolation and autotransplantation of islets after pancreatectomy.
Where Have All the Pancreas Transplants Gone and What Needs to Change?
To shed light on the multiple factors impacting a decline in pancreas transplant volume and to present strategies that individual transplant centers can implement to increase their volumes, this work discusses the reasons underlying the declining numbers and highlights specific strategies that can be implemented at centers to increase individual pancreAS transplant center volumes.
Pancreas Transplantation in Black, Asian and Minority Ethnic Patients-Single Centre Experience in the UK
Ethnic disparities in the outcomes after simultaneous pancreas kidney (SPK) transplantation still exist. The influence of ethnicity on the outcomes of pancreas transplantation in the UK has not been
Simultaneous pancreas-kidney transplantation and the impact of postoperative complications on hospitalization cost.
Considering patients who underwent SPKT, postoperative complications, reoperation, and graft pancreatectomy, as well as surgical, infectious, clinical, and immunological complications, significantly increased the mean cost of hospitalization.


Long-term benefits of pancreas transplantation
Pancreas transplantation remains the most effective method to establish durable normoglycemia for patients with diabetes mellitus and well designed clinical studies to assess outcomes and adverse events will be of paramount importance in providing optimal care to patients with Diabetes mellitus.
Survival after pancreas transplantation in patients with diabetes and preserved kidney function.
From 1995-2000, survival for those with diabetes and preserved kidney function and receiving a solitary pancreas transplant was significantly worse compared with the survival of waiting-list patients receiving conventional therapy.
Pancreas transplantation in type 1 diabetes.
Pancreas or islet transplantations should be performed in tertiary care centers that have an active kidney transplant program and are equipped to adequately handle the complex medical and psychosocial needs of transplant patients over the long term.
The success of early solitary pancreas transplantation may well be at the stage to consider a trial in selected type 1 diabetic patients at risk for renal and retinal disease.
Pancreas transplantation for type 2 diabetes mellitus.
Evidence is provided that selected patients with type 2 diabetes mellitus (T2DM) may benefit from vascularized pancreas transplantation (PTX) and characterization of the 'type' of diabetes may be irrelevant and insulin-requiring diabetic patients with ESRD should be evaluated for PTX based exclusively on their predicted ability to tolerate the surgical procedure and requisite immunosuppression.
Mortality Assessment for Pancreas Transplants
  • R. Gruessner, D. Sutherland, A. Gruessner
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2004
In this retrospective observational cohort study, patients with multiple listings at different transplant centers and patients who changed transplant centers were counted only once and the Social Security Death Master File and the UNOS kidney transplant database were used to update mortality information.
Pancreas transplant options for patients with type 1 diabetes mellitus and chronic kidney disease: simultaneous pancreas kidney or pancreas after kidney?
  • A. Wiseman
  • Medicine
    Current opinion in organ transplantation
  • 2012
Current data regarding pancreas treatment options are synthesized and couple this with a discussion of current organ utilization to better understand the advantages and disadvantages of each of these strategies.
Risks and benefits of transplantation in the cure of type 1 diabetes: whole pancreas versus islet transplantation. A single center study.
The results support the practice of listing patients for PTA when the metabolic control and the progression of chronic complications require a rapid normalization of glucose levels, with the exception of patients with cardiovascular disease, because of the high surgical risks.