Pancreas-specific ablation of beta1 integrin induces tissue degeneration by disrupting acinar cell polarity.


BACKGROUND & AIMS Integrin contact with basement membrane is a major determinant of epithelial cell polarity. beta1 integrin heterodimers are the primary receptors for basement membrane in pancreatic acinar cells, which function to synthesize and directionally secrete digestive enzymes into a central lumen. Aberrant acinar secretion and exposure of the… (More)
DOI: 10.1053/j.gastro.2010.02.043

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