Pancreas-Specific Deletion of β-Catenin Reveals Wnt-Dependent and Wnt-Independent Functions during Development

@article{Dessimoz2005PancreasSpecificDO,
  title={Pancreas-Specific Deletion of β-Catenin Reveals Wnt-Dependent and Wnt-Independent Functions during Development},
  author={Jessica Dessimoz and Claude Bonnard and Joerg Huelsken and Anne Grapin-Botton},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={1677-1683}
}
Mutations and deregulation of adenomatous polyposis coli (APC) and beta-catenin are implicated in specific cancers of the pancreas, but the role of Wnt pathway in normal pancreas development and homeostasis is unknown. This article reports a comprehensive investigation of the activity and the role of the Wnt pathway in pancreas organogenesis. We have used two reporter lines to monitor canonical Wnt pathway activity during development and after birth and demonstrate activity in endocrine cells… CONTINUE READING