Pancortins interact with amyloid precursor protein and modulate cortical cell migration.

  title={Pancortins interact with amyloid precursor protein and modulate cortical cell migration.},
  author={Heather Caroline Rice and Matthew T Townsend and Jilin Bai and Seiyam Suth and William A Cavanaugh and Dennis J Selkoe and Tracy L Young-Pearse},
  volume={139 21},
Neuronal precursor cell migration in the developing mammalian brain is a complex process requiring the coordinated interaction of numerous proteins. We have recently shown that amyloid precursor protein (APP) plays a role in migration into the cortical plate through its interaction with two cytosolic signaling proteins, disabled 1 (DAB1) and disrupted in schizophrenia 1 (DISC1). In order to identify extracellular factors that may signal through APP to regulate migration, we performed an… CONTINUE READING
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