Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells.

@article{Jin2003PanaxadiolSI,
  title={Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells.},
  author={Ying Hua Jin and JoonSeok Choi and Soona Shin and Kwang Youl Lee and Jeong Hill Park and Seung Ki Lee},
  journal={Carcinogenesis},
  year={2003},
  volume={24 11},
  pages={1767-72}
}
We show that panaxadiol (PD), a ginseng saponin with a dammarane skeleton, selectively interferes with the cell cycle in human cancer cell lines. PD inhibited DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 micro M in SK-HEP-1 cells and HeLa cells. PD-treated cells were arrested at G1/S phase, which coincided well with decreases in Cyclin A-Cdk2 activity, but not in Cyclin E-Cdk2 and Cdc2 activities. The intracellular levels of p21WAF1/CIP1 were significantly… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Activity and nature of p 21 WAF 1 = CIP 1 complexes during the cell cycle

B. D. Dynlacht
Proc . Natl Acad . Sci . USA • 1998

GinsenosideRg5 suppresses cyclin E-dependent protein kinase activity via upregulating p21and down-regulating cyclin E in SK-HEP-1 cells

K. Y. Lee, Y. H. Lee, S. I. Kim, J. H. Park, S. K. Lee
Anticancer Res., • 1997

Similar Papers

Loading similar papers…